Paper Information

Journal:   JOURNAL OF APPLIED CHEMICAL RESEARCH (JACR)   2017 , Volume 11 , Number 1; Page(s) 107 To 113.
 
Paper:  ONE-POT MULTI-COMPONENT SYNTHESIS OF DIHYDROPYRIMIDINONES VIA BIGINELLI CONDENSATION
 
Author(s):  SARGORDAN ARANI MOHSEN*, MIRZA BEHROOZ, MOGHANLOU MOHAMMAD
 
* DEPARTMENT OF CHEMISTRY, FACULTY OF SCIENCE,YADEGAR-E-IMAM KHOMEINI (RAH), SHAHR-E-REYBRANCH, ISLAMIC AZAD UNIVERSITY, TEHRAN, IRAN
 
Abstract: 

Three-component reactions have emerged as useful methods because the combination of three components to generate new products in a single step is extremely economical, among the multi-component reactions. A green, simple, efficient, and cost-effective procedure has been carried out by the synthesis of dihydropyrimidinonesin Biginelli’s condensation of ethyl cyanoacetate, aldehyde and urea or thiourea. H3BO3, H2C2O4, Me3SiCl (TMSCl) using as catalyst and compared product yield. Products were characterized with IR, 1H NMR, 13C NMR and mass spectroscopy.

 
Keyword(s): BIGINELLI REACTION, DIHYDROPYRIMIDINONES, ONE-POT SYNTHESIS, ETHYL CYANOACETATE