Paper Information

Journal:   JOURNAL OF APPLIED CHEMICAL RESEARCH (JACR)   2017 , Volume 11 , Number 1; Page(s) 21 To 33.
 
Paper:  EXTRACTION OF CEPHALEXIN USING AQUEOUS TWO-PHASE SYSTEMS COMPOSED OF CHOLINIUM CHLORIDE AND K3PO4
 
Author(s):  MOKHTARI AFSHIN, SHAHRIARI SHAHLA*
 
* DEPARTMENT OF CHEMICAL ENGINEERING, SHAHR-E-QODS BRANCH, ISLAMIC AZAD UNIVERSITY, TEHRAN, IRAN
 
Abstract: 

Cephalexin is an important antibiotic. It is very significant to determine an appropriate method for the extraction of this valuable antibiotic for industrial applications. Aiming at developing an efficient method for the extraction of cephalexin, the partitioning of cephalexin has been evaluated in aqueous two-phase system, including cholinium chloride and potassium phosphate. The effect of three main and independent variables on the partition coefficient of cephalexin has been estimated. These variables are as follows: equilibrium temperature, different weight percent of salt, and cholinium chloride. The results showed that by increasing the salt weight percent and the temperature, the partition coefficient of cephalexin will increase, while by increasing the weight percent of cholinium chloride, its partition coefficient will decrease.

 
Keyword(s): AQUEOUS TWO-PHASE SYSTEM, CHOLINIUMCHLORIDE, CEPHALEXIN, PARTITIONING